教师简介:
一、基本情况
姓 名:陈吉龙
性 别:男
政治面貌:中国致公党党员
职 称:二级教授
职 务:院长
研究方向:兽医微生物学、兽医免疫学、动物传染病学
联系电话:0591-83789159
电子邮箱:chenjilong@fafu.edu.cn
二、受教育经历
1982-1986年福建农林大学(原福建农亚博取款快速安全) 学士
1986-1989年中国农业大学(原北京农业大学) 硕士
1989-1992年北京大学 博士
三、研究工作经历
1992.07-1994.12:中国科亚博取款快速安全遗传与发育生物学研究所(原中科院发育生物学研究所)工作,任助理研究员,副研究员(中国科亚博取款快速安全破格提拔);
1995.01-1998.06:美国爱荷华大学(University of Iowa)生物化学系博士后;
1998.07-2000.11:中国科亚博取款快速安全遗传与发育生物学研究所,任副研究员、研究员。研究组负责人,青年科学家创新小组负责人;
2000.11-2008.12:美国University of Iowa高级访问学者。出国期间因研究所合并重组,辞去中科院遗传与发育生物学研究所研究员职位并获得批准;
2008.12-2017.04:2008年中国科亚博取款快速安全“百人计划”引进回国,任中国科亚博取款快速安全微生物研究所研究员(后晋升为二级研究员),研究组长,博士生导师,国家"973"计划项目首席科学家,中国科亚博取款快速安全微生物研究所学术委员会委员和学位委员会委员;
2015-2017年:兼任中国科亚博取款快速安全大学岗位教授,中国科亚博取款快速安全特聘研究员;
2013.01-至今:福建农林大学亚博取款快速安全院长(2017年起全职),二级教授,博士生导师。享受国务院政府特殊津贴专家,福建省“百人计划”入选者,福建省高层次人才(A类),福建省“闽江学者”,福建省兽医学重点学科带头人。
四、科研项目
(1)非细胞因子依赖性的宿主早期抗病毒免疫应答机制,国家自然科学重点项目(联合基金项目),主持,直接经费:265万元,2024.01-2027.12;
(2)动物流感病毒与宿主RNA 互作机制研究,国家重点研发计划课题,主持,总经费:915万元,2021.05-2025.12;
(3)新鉴定的lncRNAs在流感病毒与宿主互作过程中的作用及其机制,国家自然科学基金重点项目,主持,直接经费:285万元,2021.01-2025.12;
(4)STATs蛋白在宿主抗流感病毒天然免疫中的功能研究,国家自然科学基金联合基金项目(联合基金),主持,直接经费:232万元,2019.01-2023.12;
五、承担课程
本科生课程:动物医学专业导论、动物病毒学、预防兽医学实验(一)、形势与政策
研究生课程:高级动物病毒学、兽医生物技术进展、预防兽医学专题、兽医公共卫生学、科技论文写作
六、科研成果
陈吉龙教授长期从事兽医微生物与兽医免疫学、兽医传染病领域科研和教学工作,任国家“973”计划项目首席科学家(2015-2019),先后主持国家自然科学基金重点项目、国家重点研发计划课题、国家“973”计划项目、国家“863”计划课题、国家科技支撑课题等20多个国家级项目;在国内外重要学术刊物上发表论文120多篇,包括以第一作者或通讯作者在国际核心学术刊物Cell Host & Microbe、Lancet、The Lancet Infectious Diseases、PNAS、Nucleic Acids Research、mBio、Blood、PLoS Pathogens、Cancer Research、Cell Reports、Oncogene、Journal of Virology等杂志上发表90多篇SCI论文;获授权发明专利12项;获得福建省自然科学奖二等奖1项(排名第一)、中国侨联中国侨界贡献奖二等奖1项(个人奖)、大北农科技奖创新奖二等奖1项(排名第一)、福建省教学成果特等奖1项(排名第三)、福建省五一先锋号等多项奖励;多次应邀在国际会议上做学术报告或主持会议,得到国际同行的高度认可。
七、代表性论文与著作
Biao Chen#, Guijie Guo#, Guoqing Wang#, Qianwen Zhu, Lulu Wan, Wenhao Shi, Song Wang, Yuhai Chen, Xiaojuan Chi, Faxin Wen, Mohamed Maarouf, Shile Huang, Zhou Yang and Ji-Long Chen*. ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus. PLOS Pathogens. 2024, 20(1):e1011958. (*为通讯作者,下同)
ShashaLiu#, Siya Liu#, Ziding Yu#, Wenzhuo Zhou, Meichun Zheng, RongrongGu, JinxuanHong, Zhou Yang, Xiaojuan Chi, GuijieGuo, Xinxin Li, Na Chen, Shile Huang, Song Wang and Ji-Long Chen*. STAT3 regulates antiviral immunity by suppressingexcessive interferon signaling. Cell Reports. 2023;42(7):112806.
KulRaj Rai#, Yuan Liao#, MengjuanCai#, HaoriQiu, Faxin Wen, Min Peng, Song Wang,Shasha Liu, GuijieGuo, Xiaojuan Chi, Mohamed Maarouf, Yuhai Chen, Shile Huang and Ji-Long Chen*. MIR155HG plays abivalent role in regulating innate antiviral immunity by encoding longnoncoding RNA-155 and microRNA-155-5p. mBio. 2022, e0251022 .
Yun Ma#, GuijieGuo#, Tingting Li, Faxin Wen, JianlingYang,Biao Chen, Xuefei Wang and Ji Long Chen*. A novel imatinib-upregulated long noncoding RNA plays acritical role in inhibition of tumor growth induced by Abl oncogenes. Molecular Cancer. 2022, 21(1):5.
Yingying Li, Shasha Liu, Yuhai Chen, Biao Chen, Meng Xiao, Bincai Yang, Kul Raj Rai,MohamedMaarouf, GuijieGuo* and Ji-Long Chen*. Syk facilitates influenza A virus replication by restraining innate immunityat the late stage of viral infection. Journal of Virology. 2022; doi:10.1128/jvi.00200-22 [51].
Shasha Liu Yuan Liao, Biao Chen, Yuhai Chen, Ziding Yu, Haitao Wei, Lianfeng Zhang, Shile Huang, Paul B. Rothman, George Fu Gao and Ji-Long Chen*. Critical role of Syk-dependent STAT1 activation ininnate antiviral immunity. Cell Reports, 2021,34(3):108627. doi:10.1016/j.celrep.2020.108627.
Meng Xiao, Yuhai Chen, Song Wang, ShashaLiu,Kul Raj Rai, Biao Chen, Fang Li, Yingying Li, Mohamed Maarouf and Ji-Long Chen*. Long Noncoding RNAIFITM4P regulates host antiviral responses by acting as a ceRNA. Journal of Virology, 2021,doi: 10.1128/JVI.00277-21.
Qingsen Wang, Wenliang Pan, Song Wang, Chen Pan, Hongya Ning, Shile Huang, Shih-HsinChiu* and Ji-Long Chen*. Protein tyrosine phosphatase SHP2 suppresses host innate immunity againstinfluenza A virus through regulating EGFR-mediated signaling. Journal of Virology, 2021,95(6):e02001-20.
Biao Chen, Yuhai Chen, Kul Raj Rai, XuefeiWang,Shasha Liu, Yingying Li, Meng Xiao, Yun Ma, Guoqing Wang, GuijieGuo, Shile Huang and Ji-Long Chen*. Deficiencyof eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity. Frontiers in Immunology. 2021;12:723885. doi: 10.3389/fimmu.2021.723885.
Kul Raj Rai, Biao Chen, Zhonghui Zhao, YuhaiChen, Jiayue Hu, Shasha Liu, Mohamed Maarouf, Yingying Li, Meng Xiao, Yuan Liao and Ji-Long Chen*. Robustexpression of p27Kip1 induced by viral infection is critical for antiviralinnate immunity. Cellular Microbiology. 2020, e13242.
Jiayue Hu, George Fu Gao and Ji-Long Chen*. Strengthening the role of ethnic minority women in science and medicineinChina. Lancet, 2019;393(10171):527-528.
Ye Chen, Jin Tian and Ji-Long Chen*. Challenges to eliminaterabies virus infection inChina by 2020. The Lancet Infectious Diseases, 2017,17(2): 135-136.
Fang Li, Yuhai Chen, Zhaoyuan Zhang, Jing Ouyang, Yi Wang, Ruoxiang Yan, Shile Huang, George Fu Gao, GuijieGuo and Ji-Long Chen*. Robust expression of vault RNAs induced by influenza A virus plays a critical role in suppression of PKR-mediated innate immunity. Nucleic Acids Research, 2015; 43(21):10321-37.
Jing Ouyang, Xiaomei Zhu, Yuhai Chen, Haitao Wei, Qinghuang Chen, Xiaojuan Chi, Baomin Qi, Lianfeng Zhang, Yi Zhao, George Fu Gao, Guoshun Wang and Ji-Long Chen*. NRAV, a Long Noncoding RNA, Modulates Antiviral Responses through Suppression of Interferon-Stimulated Gene Transcription. Cell Host & Microbe, 2014; 16(5):616-626.
Haitao Wei, Song Wang, Qinghuang Chen, Yuhai Chen, Xiaojuan Chi, Lianfeng Zhang, Shile Huang, George Fu Gao and Ji-Long Chen*. Suppression of Interferon Lambda Signaling by SOCS-1 Results in Their Excessive Production during Influenza Virus Infection. PLoS Pathogens, 2014; 10(1):e1003845.
Song Wang, Xiaojuan Chi, Haitao Wei, Yuhai Chen, Zhilong Chen, Shile Huang and Ji-Long Chen*. Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to the viral replication by suppressing IFITM3 protein expression. Journal of Virology, 2014; 88(15):8375-8385.
Jianling Yang, Jun Wang, Ke Chen, GuijieGuo, Ruijiao Xi, Paul B. Rothman, Douglas Whitten, Lianfeng Zhang, Shile Huang and Ji-Long Chen*. eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes. Cancer Research, 2013; 73(15): 4898-4908.
Song Wang, Hua Li, Yuhai Chen, Haitao Wei, George F.Gao. , Hongqiang Liu, Shile Huang and Ji-Long Chen*. Transport of influenza A virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42. The Journal of Biological Chemistry, 2012, 287 (13): 9804-9816.
GuijieGuo, Qingzheng Kang, Xiaomei Zhu, Qinghuang Chen, Xuefei Wang, Yuhai Chen, Jing Ouyang, Lianfeng Zhang, Huo Tan, RunshengChen,Shile Huang and Ji-Long Chen*. A long noncoding RNA critically regulates Bcr-Abl-mediatedcellular transformation by acting as a competitive endogenous RNA. Oncogene, 2015;34(14):1768-1779.
GuijieGuo, XiaoxueQiu, Song Wang, Yuhai Chen, Paul B. Rothman, Zixu Wang, YaoxingChen, Guoshun Wang and Ji-Long Chen*. The oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B cell transformation and survival of Pim-deficient cells. Oncogene, 2010,29:3845–3853.
Xuefei Wang, Shile Huang and Ji-Long Chen*. Understanding of leukemic stem cells and their clinical implications. Molecular Cancer, 2017; 16(1):2.
Xuefei Wang, Jianling Yang, GuijieGuo, Riyue Feng, Ke Chen, Yuan Liao, Lianfeng Zhang, Liping Sun, Shile Huang and Ji-Long Chen*. Novel lncRNA-IUR suppresses Bcr-Abl-induced tumorigenesis through regulation of STAT5-CD71 pathway. Molecular Cancer, 2019,18(1):84-95.
Song Wang, Lanlan Zhang, Rong Zhang, Xiaojuan Chi, Zhou Yang, YanhuiXie, Sicheng Shu, Yuan Liao and Ji-Long Chen*. Identification of two residues within the NS1 of H7N9 influenza A virus that critically affect the protein stability and function. Veterinary Research, 2018,49(1):98.
Yuhai Chen, Jing Ouyang, Ruoxiang Yan, Mohamed Hassan Maarouf, Xuefei Wang, Biao Chen, Shasha Liu, Jiayue Hu, GuijieGuo, Jing Zhang, Sheng-Ming Dai, Huji Xu and Ji-Long Chen*. Silencing SOCS3 Markedly Deteriorates Spondyloarthritis in Mice Induced by Minicircle DNA Expressing IL23. Frontiers in Immunology. 2018,9:2641. doi: 10.3389/fimmu.2018.02641.
Riyue Feng, Xuefei Wang, Ke Chen, GuijieGuo, Yuan Liao, Liping Sun, Shile Huang and Ji-Long Chen*. Interaction of Abl Tyrosine Kinases with SOCS3 Impairs Its Suppressor Function in Tumorigenesis. Neoplasia, 2018,20(11):1095-1105.
Xiaoyong Chen, Shasha Liu, Mohamed Maarouf, Shile Huang and Ji-Long Chen*. Host immune response to influenza A virus infection. Frontiers in Immunology. 2018; 9:320.
Shi-long Chen, Guifeng Luo, Zhou Yang, Shuncheng Lin, Shaoying Chen, Song Wang, MohsanUlahGoraya, Xiaojuan Chi, Xiancheng Zeng and Ji-Long Chen*. Avian Tembusu virus infection effectively triggers host innate immune response through MDA5 and TLR3-dependent signaling pathways. Veterinary Research, 2016; 47(1):74.
Jingyun Wei, Yanmei Ma, Long Wang, Xiaojuan Chi, Ruoxiang Yan, Song Wang, Xinxin Li, Xiaoyong Chen, Wenhan Shao and Ji-Long Chen*. Alpha/beta interferon receptor deficiency in mice significantly enhances susceptibility of the animals to pseudorabies virus infection. Veterinary Microbiology. 2017; 203:234-244.
BinxiangCai, Qingling Bai, Xiaojuan Chi, MohsanUllahGoraya, Long Wang, Song Wang, Biao Chen and Ji-Long Chen*. Infection with classical swine fever virus induces expression of type III interferons and activates innate immune signaling. Frontiers in Microbiology, 2017;8:2558.
Song Wang, Xiaoqin Luo, Ruoxiang Yan, Quanxin Wang, Qiuyue Qi, Xiaojuan Chi, Lanlan Zhang, ZidingYu ,BinxiangCai, Ji-Long Chen* and Hongwei Liu*. 3-anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection. Protein & cell, 2016; 7(11):839-843.
Jing Ouyang, Jiayue Hu and Ji-long Chen*. lncRNAs regulate the innate immune response to vi